Effect of Perioperative Acetaminophen Dosing on Patients Undergoing Surgical Treatment of Basilar Thumb Arthritis

  • End date
    Sep 23, 2023
  • participants needed
  • sponsor
    Indiana Hand to Shoulder Center
Updated on 23 October 2022


Basilar thumb arthritis is a common problem that affects 7% of men and 15% of women. It is regarded as one of the more painful procedures commonly performed by hand surgeons. Opioid overuse and diversion are significant problems in the country that contribute to opioid addiction as well as deaths from opioid overdose. Prior studies have examined the effect of different nerve block compositions on perioperative and postoperative analgesia, but none have looked at perioperative loading analgesia. We will attempt to address this problem by exploring alternative analgesia regimens to decrease opioid prescribing after 1st carpometacarpal (CMC) joint arthroplasty.

Condition Carpometacarpal Osteoarthritis
Treatment Acetaminophen, Placebo: Multivitamin
Clinical Study IdentifierNCT05556356
SponsorIndiana Hand to Shoulder Center
Last Modified on23 October 2022


Yes No Not Sure

Inclusion Criteria

Adults (18 years of age or older)
Patients presenting with symptomatic 1st CMC arthritis with or without scaphotrapeziotrapezoid arthritis
Eaton Classification stage II, III, or IV OA of the first CMC joint based on xrays
Patients who plan to undergo a ligament reconstruction and tendon interposition (LRTI) or thumb suspensionplasty procedure within 6 months of enrolling to study
Bilateral thumbs included

Exclusion Criteria

<18 years age
Prior surgical history of ipsilateral 1st CMC arthroplasty or procedures involving thumb CMC joints
Prior ipsilateral tendon rupture or ipsilateral peripheral nerve palsy
History of opioid dependency or current chronic opioid use
Contraindication to acetaminophen use
Contraindication to NSAID use
Contraindication or known allergy to peripheral nerve blockade, including coagulopathy
Contraindication to supraclavicular block due to anatomic variability or inability to tolerate phrenic nerve blockade
Contraindication to multivitamin use
Liver dysfunction
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact


Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note