Effect of Perioperative Acetaminophen Dosing on Patients Undergoing Surgical Treatment of Basilar Thumb Arthritis

  • STATUS
    Recruiting
  • End date
    Sep 23, 2023
  • participants needed
    50
  • sponsor
    Indiana Hand to Shoulder Center
Updated on 23 October 2022

Summary

Basilar thumb arthritis is a common problem that affects 7% of men and 15% of women. It is regarded as one of the more painful procedures commonly performed by hand surgeons. Opioid overuse and diversion are significant problems in the country that contribute to opioid addiction as well as deaths from opioid overdose. Prior studies have examined the effect of different nerve block compositions on perioperative and postoperative analgesia, but none have looked at perioperative loading analgesia. We will attempt to address this problem by exploring alternative analgesia regimens to decrease opioid prescribing after 1st carpometacarpal (CMC) joint arthroplasty.

Details
Condition Carpometacarpal Osteoarthritis
Treatment Acetaminophen, Placebo: Multivitamin
Clinical Study IdentifierNCT05556356
SponsorIndiana Hand to Shoulder Center
Last Modified on23 October 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Adults (18 years of age or older)
Patients presenting with symptomatic 1st CMC arthritis with or without scaphotrapeziotrapezoid arthritis
Eaton Classification stage II, III, or IV OA of the first CMC joint based on xrays
Patients who plan to undergo a ligament reconstruction and tendon interposition (LRTI) or thumb suspensionplasty procedure within 6 months of enrolling to study
Bilateral thumbs included

Exclusion Criteria

<18 years age
Prior surgical history of ipsilateral 1st CMC arthroplasty or procedures involving thumb CMC joints
Prior ipsilateral tendon rupture or ipsilateral peripheral nerve palsy
History of opioid dependency or current chronic opioid use
Contraindication to acetaminophen use
Contraindication to NSAID use
Contraindication or known allergy to peripheral nerve blockade, including coagulopathy
Contraindication to supraclavicular block due to anatomic variability or inability to tolerate phrenic nerve blockade
Contraindication to multivitamin use
Liver dysfunction
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