Comparing Rapid Micro-Induction and Standard Induction of Buprenorphine/Naloxone for Treatment of Opioid Use Disorder: A Randomized Controlled Trial
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- STATUS
- Recruiting
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- End date
- May 23, 2023
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- participants needed
- 50
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- sponsor
- University of British Columbia
Summary
The current first-line treatment for opioid use disorder (OUD) in Canada is buprenorphine/naloxone (bup/nx). The standard induction method of bup/nx requires patients to be abstinent from opioids and thereby experience withdrawal symptoms prior to induction, which can be a major barrier in starting treatment. Rapid micro-induction (also known as micro-dosing, low-dose induction) involves the administration of small, frequent does of bup/nx and removes the need for a period of withdrawal prior to the start of treatment. This study aims to compare the effectiveness and safety of rapid micro-induction versus standard induction of bup/nx in patients with OUD.
Description
This is a randomized, controlled, open-label superiority trial involving 50 individuals with OUD. Participants will be randomized into two arms: rapid micro-induction and standard induction (based on the American Society of Addiction Medicine Practice Guidelines and product monograph) of bup/nx.
Details
| Condition | Opioid Use Disorder |
|---|---|
| Treatment | Hydromorphone, Buprenorphine/naloxone |
| Clinical Study Identifier | NCT04234191 |
| Sponsor | University of British Columbia |
| Last Modified on | 23 October 2022 |
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