Hospital Airway Resuscitation Trial (HART)

  • sponsor
    National Institutes of Health (NIH); National Heart, Lung, and Blood Institute (NHLBI)
Updated on 7 October 2022


Cardiac arrest occurring in the hospital is a major burden to patients and their families. Different ways to manage the breathing of patients with cardiac arrest in the hospital are currently being used and it is not clear which is best. This study will help us understand if one approach to giving oxygen during cardiac arrest is better than another, which will be important for future patients suffering cardiac arrest.


What is a cardiac arrest?
A cardiac arrest occurs when the heart completely stops and blood is not flowing through the body. Cardiac arrest is an uncommon but unfortunately very harmful event for patients in the hospital. Most patients who suffer a cardiac arrest do not survive. Many things can cause a cardiac arrest including heart attacks, electrolyte imbalances, sepsis and other serious illnesses and conditions. When a cardiac arrest occurs, rescuers typically perform chest compressions, administer shocks to the heart, and give medications to try and restart the heart.
A bit about the Hospital Airway Resuscitation Study
One important part of trying to restart the heart after cardiac arrest is getting oxygen to the lungs. There are a number of ways to do that including using a facemask, inserting a breathing tube into the lungs, or placing a specialized tube that sits in the throat on top of the lungs. All of these approaches are recommended equally by the American Heart Association and are used by doctors and emergency responders. In the Hospital Airway Resuscitation study, we are trying to compare these techniques. In the study, different hospitals are assigned to use either the tube that goes into the lungs (endotracheal intubation) or the tube that sits above the lungs (supraglottic airway) as first choice in the event of a cardiac arrest. At any time, a physician or other care provider can select the device of their choosing if one of the approaches is felt to be unsafe or an alternative approach is preferred. Because of how emergent cardiac arrest is and because hospitals and not individual patients are being assigned to the different approaches, informed consent could not be sought beforehand.

Condition Cardiovascular Abnormalities, cardiac arrest
Clinical Study IdentifierTX307744
SponsorNational Institutes of Health (NIH); National Heart, Lung, and Blood Institute (NHLBI)
Last Modified on7 October 2022


Yes No Not Sure

Inclusion Criteria

Adult aged >17 years old
Admitted to the hospital for any condition
Suffered in-hospital cardiac arrest (loss of pulse and ≥2 minutes of chest compressions)
Need for assisted ventilation (defined by initiation of bag-mask-ventilation or other supported ventilation

Exclusion Criteria

Cardiac arrest in the Operating Room or other area not responded to by critical care/ED teams
Cardiac arrest in which an invasive airway (i.e. endotracheal tube, tracheostomy tube) is already in place
Patients with clear asphyxia arrest due to upper airway obstruction (e.g. foreign body, angioedema, malignancy) as determined the clinical team
Patients with Do Not Resuscitate or Do Not Intubate orders
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Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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