Trained Immunity of Myeloid Cells and Their Progenitors in Patients With Non-medullary Thyroid Carcinoma and Colon Carcinoma

  • STATUS
    Recruiting
  • End date
    Apr 7, 2025
  • participants needed
    60
  • sponsor
    Radboud University Medical Center
Updated on 19 October 2022

Summary

Tumor-related inflammation is one of the hallmarks of cancers in general. Innate immunity specifically is a common denominator which is involved in the pathogenesis of both thyroid carcinoma and colon carcinoma. To improve the patient's outcome and identify novel therapeutic targets, one needs a deeper understanding of the tumor-induced changes in the bone marrow myeloid progenitor cells. Furthermore, treatment of these cells by nanoparticles or other agents that induce a program of 'trained immunity' may be a novel way to re-educate myeloid cells and their bone marrow progenitors in thyroid carcinoma patients. Lastly, the investigators expect that this approach could be effective also in other cancers of which colon carcinoma is here proposed as an additional model.

The investigators hypothesize that by exposing myeloid cells or their progenitors to various agents that induce trained immunity (e.g. high-density-lipoprotein-methylene diphosphonate nanoparticles, recombinant and synthetic cytokines), these immune cells will undergo functional reprogramming to induce a tumor-suppressive phenotype. In the future, this could be explored as a novel immunotherapy for tumors that are refractory to conventional treatment.

Details
Condition Thyroid Cancer, Nonmedullary, Colon Carcinoma
Treatment no intervention will take place
Clinical Study IdentifierNCT05280379
SponsorRadboud University Medical Center
Last Modified on19 October 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

At least 18 years old and mentally competent
Newly diagnoses non-medullary thyroid carcinoma or colon carcinoma that is therapy naïve
Planned to receive conventional treatment for the malignancy by surgery

Exclusion Criteria

Mentally incompetent
Pregnant or breastfeeding
Known inflammation or infectious disease or an immunosuppressive status
Using medication interfering with the immune system
Reduced platelets counts or other conditions associated with an increased risk of bleeding
Severe comorbidities: other active malignancy (except for basal cell carcinoma and other in situ carcinomas)
Previous anti-cancer treatment, such as chemotherapy, radiotherapy or surgical removal or the primary tumor
Serious psychiatric pathology
A self-reported alcohol consumption of >21 units per week
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