The Effects of NSAIDs on Bone Metabolism Following Exercise
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- STATUS
- Recruiting
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- days left to enroll
- 11
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- participants needed
- 12
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- sponsor
- United States Army Research Institute of Environmental Medicine
Summary
The purpose of this study is to determine the effects of a single dose of non-steroidal anti-inflammatory drugs on post-exercise markers of bone and muscle metabolism.
Description
This protocol intends to determine how consuming a single dose of a non-steroidal anti-inflammatory drug (NSAID) affects circulating bone metabolism biomarkers and markers of damage skeletal muscle in response to a bout of plyometric exercise. This will be accomplished using a four trial, placebo-controlled crossover design with trials examining ibuprofen, celecoxib, flurbiprofen and placebo. These particular NSAIDs were chosen because of their widespread use in military populations and differing molecular mechanisms, which could cause differing effects on bone and muscle. Two hours after of consuming a single dose of an NSAID, participants will perform 10 sets of 10 plyometric jumps to induce a mechanical loading stimulus the bone and muscle tissues. Blood, urine, and muscle biopsy samples will be collected before and up to four hours after exercise. Biomarkers representing bone and muscle metabolism will determine the magnitude of adaptive responses to plyometric exercise while using NSAIDs.
Details
| Condition | Bone Resorption, Stress Fracture, Bone Injury |
|---|---|
| Treatment | Placebo, Celecoxib 200mg, Ibuprofen 800 mg, Flurbiprofen 100 mg |
| Clinical Study Identifier | NCT05512013 |
| Sponsor | United States Army Research Institute of Environmental Medicine |
| Last Modified on | 4 October 2022 |
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