The Effects of NSAIDs on Bone Metabolism Following Exercise

  • participants needed
  • sponsor
    United States Army Research Institute of Environmental Medicine
Updated on 31 May 2023
Accepts healthy volunteers


The purpose of this study is to determine the effects of a single dose of non-steroidal anti-inflammatory drugs on post-exercise markers of bone and muscle metabolism.


This protocol intends to determine how consuming a single dose of a non-steroidal anti-inflammatory drug (NSAID) affects circulating bone metabolism biomarkers and markers of damage skeletal muscle in response to a bout of plyometric exercise. This will be accomplished using a four trial, placebo-controlled crossover design with trials examining ibuprofen, celecoxib, flurbiprofen and placebo. These particular NSAIDs were chosen because of their widespread use in military populations and differing molecular mechanisms, which could cause differing effects on bone and muscle. Two hours after of consuming a single dose of an NSAID, participants will perform 10 sets of 10 plyometric jumps to induce a mechanical loading stimulus the bone and muscle tissues. Blood, urine, and muscle biopsy samples will be collected before and up to four hours after exercise. Biomarkers representing bone and muscle metabolism will determine the magnitude of adaptive responses to plyometric exercise while using NSAIDs.

Condition Bone Resorption, Stress Fracture, Bone Injury
Treatment Placebo, Celecoxib 200mg, Ibuprofen 800 mg, Flurbiprofen 100 mg
Clinical Study IdentifierNCT05512013
SponsorUnited States Army Research Institute of Environmental Medicine
Last Modified on31 May 2023

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