Cardiac Output in Preeclamptic (Coload)

  • days left to enroll
  • participants needed
  • sponsor
    Mansoura University
Updated on 7 October 2022


There is high incidence of hypertensive disorders during pregnancy.The maternal cardiovascular system had significant changes during pregnancy. The colloid oncotic pressure is decreased during preeclampsia.


Transthoracic echocardiography considered an accurate non-invasive device and has validity for measuring cardiac functions in pregnancy.

Condition Echocardiography
Treatment 1000 mL of ringer's acetate solution, 250 mL 6% hydroxyethyl starch (Voluven) then 500 mL of ringer's acetate solution then 250 mL of 6% hydroxyethyl starch (Voluven)
Clinical Study IdentifierNCT05435573
SponsorMansoura University
Last Modified on7 October 2022


Yes No Not Sure

Inclusion Criteria

Age 18-45 years
Singleton pregnancy scheduled for elective CS delivery under spinal anesthesia
American Society of Anesthesiologists (ASA Ⅱ, Ⅲ)

Exclusion Criteria

Body mass index < 18 or ≥40 kg/m²
Women presenting in labor
Current administration of vasoactive drugs including salbutamol and thyroxin
Diabetes mellitus
Hemoglobin <10 g/dl
Cardiovascular, cerebrovascular, or renal disease
Increased serum creatinine level ≥1.1 mg/dL
Contraindications to spinal anesthesia:(increased intracranial pressure, coagulopathy, or local skin infection)
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