Perioperative Exercise and Nutritional Optimisation Prehabilitation Before Surgery for Patients With Peritoneal Malignancy (PANO)

  • End date
    Mar 1, 2024
  • participants needed
  • sponsor
    Dublin City University
Updated on 7 October 2022
cancer chemotherapy
intraperitoneal chemotherapy
cancer of the ovary


People who are diagnosed with cancer of the colon/rectum/appendix/ovaries that spreads into the lining of the tummy and some ovarian cancers or people with pseudomyxoma peritonei can often undergo intensive treatment including major surgery where chemotherapy is given whilst the person is having surgery - also known by doctors as surgery and hyperthermic intraperitoneal chemotherapy (HIPEC). Fitness for this surgery can improve if people undertake a prehabilitation programme at the time they get their diagnosis. To date, little research has focused on how exercise and nutrition support before surgery can help these patients during recovery. The aim of this study is to explore the use of exercise and nutritional support pre-treatment to enhance physical and psychological outcomes for patients.


The comparator in this study will be standard oncological care. Control patients will receive the same care as standard without the addition of a formal exercise and nutrition support programme. The pre-treatment (prehabilitation) programme will commence following diagnosis and continue up to the point of surgery and recommence for six weeks following surgery when deemed clinically fit to participate. Assessments will occur at baseline, pre-surgery, post-surgery, and 6 weeks later and a follow up... Mixed methods will be employed with patients taking part in self-report assessments, physical assessments, and qualitative interviews. The primary aim of the study is to assess the feasibility of the intervention and cardiorespiratory fitness pre-surgery. The secondary aims include assessing the effect of the intervention on physical health, psychological wellbeing, health-related quality of life, self-efficacy, nutrition, and serology markers. Exploratory aims also include post-operative morbidity, health economics analysis and qualitative interview of patient experience.

Condition Peritoneal Malignancy, Ovarian Cancer, Rectum Cancer, Appendix Cancer, Colon Cancer
Treatment Exercise, nutrition
Clinical Study IdentifierNCT05305820
SponsorDublin City University
Last Modified on7 October 2022


Yes No Not Sure

Inclusion Criteria

age ≥18 years
multidisciplinary team referral for CRS-HIPEC for colorectal/appendix/ovarian peritoneal disease or pseudomyxoma peritonei (+/- completed neoadjuvant cancer treatment)
WHO performance status ≤2

Exclusion Criteria

inability to provide informed consent
impaired cognitive function with a reduced ability to either understand advice /instructions from or communicate with the research team
declined surgery
surgery in less than 2 weeks
pregnancy or breastfeeding
inability to participate in the exercise training (unable to perform the 6 Minute Walk Test)
absolute contraindications to exercise testing, veganism
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