Impact of Real-time Notification of Colonoscopic Optical Diagnosis on Patients' Anxiety and Depression After Polypectomy

  • End date
    Aug 31, 2025
  • participants needed
  • sponsor
    Fu Jen Catholic University
Updated on 7 October 2022
colorectal polyps
depressed mood
endoscopic resection


The accuracy of endoscopic optical diagnosis for colorectal polyps has been approaching histological diagnosis after implementation of image enhancement endoscopic technologies. The real-time notification of possible nature of resected polyp after colonoscopy is expected to reduce the anxiety and depression level of the patients before the availability of histological diagnosis and improve their quality of life. We designed and conducted a randomized control trial to confirm this hypothesis.


This is a single center, open-label, prospective and parallel randomized controlled trial. This study planning to recruit outpatients from the age of 40 to 79 who are scheduled to undergo sedated colonoscopy. Once eligible subjects were diagnosed of colorectal polyps during colonoscopy and received polypectomy, they will be randomized into "ordinary care group (explained at next scheduled clinic)" and "real-time notification group (explained immediately after colonoscopy)". The level of anxiety, depression of the two groups will be measured by using the Taiwan version questionnaire of Hospital Anxiety and Depression Scale (HADS) right before the next scheduled clinic for histological results and compared the difference between the two groups.This study is expected to determine the impact of real-time notification of colonoscopic optical diagnosis on patients' anxiety and depression after polypectomy, and provide evidence to improve post-polypectomy care.

Condition Colorectal Neoplasms, Colonic Polyp, Anxiety, Depression, Colonoscopy
Treatment Real-time endoscopic optical diagnosis
Clinical Study IdentifierNCT05517343
SponsorFu Jen Catholic University
Last Modified on7 October 2022


Yes No Not Sure

Inclusion Criteria

Age of ≥ 40 years and < 80 years
Outpatients who prepare receiving sedated colonoscopy
Subjects who have signed informed consent form of this study
Informed consensus has been obtained that endoscopic resection should be performed if a colorectal polyp is found
Eastern Cooperative Oncology Group (ECOG) performance status scale among 0 to 2

Exclusion Criteria

Subjects with any of the following prior history or current conditions
(a) Contraindications to colonoscopy
(b) Major mental illnesses, e.g. major depressive disorder, schizophrenia, generalized anxiety disorder
(c) Inflammatory bowel disease
(d) Hereditary or non-hereditary polyposis syndrome, hereditary non-polyposis colorectal cancer
(e) Uncured colorectal cancer
(f) Active gastrointestinal bleeding
(g) Pregnancy
Subjects who do not received polypectomy during colonoscopy
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