Triple BRAFinh/MEKinh /antiPD1 Combined Therapy in Patients With BRAF Mutated Melanoma With Central Nervous System Metastasis

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  • sponsor
    University Hospital, Montpellier
Updated on 4 October 2022


Currently, therapeutic options in BRAF mutated melanoma with brain metastasis occurring after achievement of a good control of extracerebral secondary lesions by a first line combined targeted therapy (TT) are limited. In this setting, the addition of an anti PD1 agent to TT may be proposed as a second line strategy. This observational survey aims at investigating the benefit/risk ratio of this triple combination in a small cohort of patients.

Condition Metastatic Melanoma
Clinical Study IdentifierNCT05510466
SponsorUniversity Hospital, Montpellier
Last Modified on4 October 2022


Yes No Not Sure

Inclusion Criteria

Metastatic melanoma BRAF mutated
Initially treated by a doubled targeted therapy anti BRAF/anti MEK
With an intra cerebral progression of the tumor
Whom we add an check point inhibitor anti PD1, combined with the double targeted therapy
between 01/2019 et 01/2022

Exclusion Criteria

Other condition
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