Endoscopic Radiofrequency Ablation of Celiac Ganglion for Pain Management and Improvement of Quality of Life in Patients With Unresectable Pancreatic Cancer

  • End date
    May 17, 2024
  • participants needed
  • sponsor
    West Virginia University
Updated on 7 October 2022
endoscopic ultrasound
unresectable pancreatic cancer


This study aims to evaluate the EUS-RFA in terms of efficacy for pain management and improvement in quality-of-life parameters for patients with advanced inoperable pancreatic cancer. The primary objectives of this study are to 1) evaluate the utility of EUS-RFA for pain control and improvement in quality-of-life parameters for patients with advanced pancreatic cancer; 2) to measure the reduction of analgesic medications' requirements in patients affected by inoperable pancreatic cancer.

Condition Pancreatic Cancer
Treatment Ablation of Celiac Ganglion
Clinical Study IdentifierNCT05535894
SponsorWest Virginia University
Last Modified on7 October 2022


Yes No Not Sure

Inclusion Criteria

Diagnosis of pancreatic cancer based on clinical, radiological, or pathological assessment
Referred for abdominal and/or back pain due to pancreatic cancer
No prior history of RFA
Cancer pain unresponsive to the WHO 3-step analgesic ladder
Willingness to consent to participate in the study

Exclusion Criteria

Patients who are not willing to give informed consent or agree to participate in the study
Surgically resectable pancreatic cancer
Abdominal pain with etiology other than pancreatic malignancy
Evidence of concurrent infection
Patients with irreversible coagulopathy international normalized ratio >1.5 or platelet count <50,000/mm3)
Patients with a preliminary diagnosis of adenocarcinoma are not possible established with intraprocedural at EUS-guided FNA
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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