LT for Unresectable Colorectal Liver Metastasis

  • STATUS
    Recruiting
  • End date
    May 17, 2026
  • participants needed
    20
  • sponsor
    Seoul National University Hospital
Updated on 7 October 2022

Summary

Unlike hepatocellular carcinoma, liver transplantation in patients with liver metastasis from colorectal cancer is limited in only few centers. Previously, it was not generally implemented due to lack of organs and high recurrence rates after transplantation. However, due to progressive development in treatments, good results such as increased survival rates can be expected even in liver transplant patients with liver metastasis from colorectal cancer, which is known to have poor prognosis. Therefore, the purpose of this study is to analyze the efficacy of liver transplantation as an alternative treatment for liver metastasis from colorectal cancer.

Description

Surgical treatment offers a distinct survival benefit in liver metastasis of colorectal cancer (CRC LM). However, it has been estimated that only 40% of patients are candidates for curative liver resection. Liver transplantation can be considered as one of a treatment option, since all evident disease is removed during procedure. However, it is limited in only few centers due to lack of organs and high recurrence rates after transplantation.

Currently, with help of development in treatments, prognosis after LT in CRC LM is improving. Recent study of LT for CRC LM from Norway demonstrated a 5-year survival of 56%. In addition, cohort study and randomized controlled trials are ongoing in Germany and Canada. Therefore, it seems to be necessary to verify the effectiveness of liver transplantation for CRC LM and to verify it as an alternative treatment if there is no other treatment. The purpose of this study is to analyze the efficacy of liver transplantation as an alternative treatment for liver metastasis from colorectal cancer.

Potential participants will be evaluated for liver transplantation and must also have a willing, healthy living donor. Unresectable metastasis should be limited to the liver and stable without no other treatment such as immunotherapy, chemotherapy, surgical resection, and radiofrequency ablation. The suitability of liver transplantation will be evaluated through a multidisciplinary assessment immediately before transplantation. Those participants who undergo liver transplantation will be followed for survival, disease-free survival, and recurrence for 3 years.

Details
Condition Liver Metastasis Colon Cancer
Treatment Living Donor Liver Transplantation
Clinical Study IdentifierNCT04874259
SponsorSeoul National University Hospital
Last Modified on7 October 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Proven colorectal cancer liver metastases without no other treatment (such as immunotherapy, chemotherapy, surgical resection, and radiofrequency ablation)
Metastasis isolated to liver
Patients selected as a liver transplant recipient at a multidisciplinary meeting
Paitents with a willing, healthy living donor
Willing and able to provide written informed consent

Exclusion Criteria

Pregnant women
Known history of human immunodeficiency virus (HIV) infection
Patients with active peptic ulcer within 2 weeks of transplantation
Persistent colorectal cancer after colon resection
Hemodynamically unstable prior to liver transplantation
Progression of LM at any timepoint prior to transplant surgery (assessed in a multidisciplinary meeting)
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