Oxytocin Maintenance Infusion in Labouring Women Undergoing Cesarean Delivery: an Up-down Sequential Allocation Study

  • STATUS
    Recruiting
  • days left to enroll
    14
  • participants needed
    30
  • sponsor
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Updated on 4 October 2022
Accepts healthy volunteers

Summary

This study is designed to determine the minimal effective oxytocin maintenance infusion required in labouring women undergoing cesarean delivery to achieve the best effect. Oxytocin is a drug that is routinely used to help the uterus to contract and keep it contracted after delivery. Consequently, it will help to reduce blood loss after delivery. In order to determine the minimal effective dose, the investigators will conduct a dose-finding study. The first patient will receive a set oxytocin infusion. The next patient's infusion dose of oxytocin, will either increase or decrease, depending on how the previous patient responds in terms of uterine tone. If the response is satisfactory with the infusion dose used, the next patient will either receive the same infusion dose or it will be decreased depending on a probability of 1:9. If the response is not satisfactory, then the infusion dose will increase for the next patient. The dose for each patient will be determined based on the results of the uterine contraction of the previous patient.

The investigators hypothesize that the ED90 of the oxytocin infusion rate to maintain adequate uterine tone in labouring women with induced or augmented labour undergoing cesarean delivery, following an initial effective bolus dose, would be lower than 0.74 IU/min (44 IU/h), which was found as the ED90 in a previous study, without an initial bolus dose prior to the infusion.

Description

This study will be conducted as a prospective, double blinded clinical trial (patient, anesthesiologist and obstetrician blinded to the oxytocin dose), in an up-down sequential allocation fashion. The objective of the study is to determine the minimum effective dose of oxytocin infusion required to produce appropriate uterine contraction during and after cesarean delivery under neuraxial anesthesia in laboring women. For the purpose of this study, the minimum effective dose is defined to be that at which adequate response occurs in 90% of patients, i.e. ED90.

Details
Condition Postpartum Hemorrhage
Treatment Oxytocin
Clinical Study IdentifierNCT05290129
SponsorSamuel Lunenfeld Research Institute, Mount Sinai Hospital
Last Modified on4 October 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

• All patients with induced or augmented labour undergoing cesarean delivery under
neuraxial anesthesia (at least 3 hours of prior exposure to oxytocin during labour)

Exclusion Criteria

All patients who refuse to give written informed consent
All patients who declare allergy or hypersensitivity to oxytocin
A history of hypertension and/or severe cardiac disease(s)
All patients who have contraindications for neuraxial anesthesia
All patients who will be converted to general anesthesia intraoperatively
All patients with placenta previa and multiple gestation
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