Role of Gut Microbiota in the Pathophysiology of Aseptic Abscesses (ABSCESSBIOT)

  • STATUS
    Recruiting
  • End date
    Dec 31, 2024
  • participants needed
    60
  • sponsor
    University Hospital, Clermont-Ferrand
Updated on 11 October 2022
Accepts healthy volunteers

Summary

Aseptic abscess syndrome (AA) is a rare entity characterized by the occurrence of deep abscesses with no germ found. Antibiotic therapy is ineffective and they are sensitive to anti-inflammatory treatment with corticosteroids.

Gut microbiota is important for the development of the immune system. In Crohn's disease which is frequently associated with AA syndrome, dysbiosis is found but could also be involved in the immune response at a distance from the gut.

Stool, blood, saliva and urine samples will be taken from the patients included and their controls in the centers where they are followed. These biological samples will be transported to Clermont Ferrand using the same procedure (transporter and dry ice) where the following analyses will be performed: microbiota on stool and saliva, short chain fatty acids on stool and lymphocyte study on blood.

Description

  • Included patients will be adult patients meeting the diagnostic criteria for aseptic abscess syndrome described by André et al.
    • Controls will be adults without aseptic abscess syndrome living in the same environment as the patients, whether related to the patient or not.

Patients and controls must be able to provide informed consent and be affiliated with the French Social Security system.

Details
Condition Aseptic Abscess Syndrome
Treatment biological sample collection
Clinical Study IdentifierNCT05537909
SponsorUniversity Hospital, Clermont-Ferrand
Last Modified on11 October 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

For cases: adult patients meeting the diagnostic criteria for aseptic abscess syndrome described by André et al
Deep abscesses on radiological examination with neutrophilic features proven by pathological analysis of a surgical specimen or biopsy when performed
Negative blood cultures, negative serological tests for bacteria, including always Yersinia enterocolitica, and, during surgery or aspiration, sterile pus (with standard cultures, BAAR and fungal tests) Failure of antibiotic therapy, when prescribed, after at least 2 weeks for conventional antibiotic therapy and at least 3 months for anti-tuberculosis treatment
Rapid clinical improvement the day after the prescription of corticosteroids (at least 1/2 mg/kg prednisone or equivalent) followed by radiological improvement after 1 month of corticosteroids, sometimes in association with immunosuppressive treatments
For controls: adult person living in the same environment as the case to which it is
matched. Adult person living in the same household or near the patient
For cases and controls
Ability to provide informed consent
Membership in the Social Security system

Exclusion Criteria

Pregnant women. Incapable patients Patients deprived of liberty Antibiotic therapy
administered within 6 weeks prior to inclusion
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