Immunohistochemical Study of Neurodegenerative Diseases

  • STATUS
    Recruiting
  • End date
    Apr 30, 2023
  • participants needed
    100
  • sponsor
    First Affiliated Hospital of Zhejiang University
Updated on 7 October 2022
dementia
alzheimer's disease
donepezil
neurodegenerative disorder
Accepts healthy volunteers

Summary

The subject uses cytof to analyze PBMC of sporadic AD and DLB, which is used to reveal the differences in immune characteristics of the two diseases at the single-cell level, build immune models for specific diseases, and define these two neurodegenerative diseases with high precision from the level of molecular immunity. To provide basis for further study of the immunohistochemical differences between the two diseases, and provide objective support for clinical diagnosis and differential diagnosis.

Details
Condition Alzheimer Disease, Lewy Body Disease, Neurodegenerative Diseases
Treatment Detection of cytof in peripheral PBMC, Donepezil for patients with AD and DLB
Clinical Study IdentifierNCT05518409
SponsorFirst Affiliated Hospital of Zhejiang University
Last Modified on7 October 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

AD inclusion criteria
a.Clinical diagnosis of Alzheimer's Disease
DLB inclusion criteria
Clinical diagnosis of Dementia with Lewy bodies

Exclusion Criteria

Infectious diseases
autoimmune disease
heart failure
chronic obstructive pulmonary disease (COPD)
cancer
renal failure
recently major surgery
alcohol and / or drug abuse
disturbance of consciousness
clinical diagnosis of major depression disorder
clinical diagnosis of Anxiety disorder
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