Evaluation of Gut Permeability in Patients Affected by Obesity and NAFLD: Influence of Ketogenic Diet.

  • participants needed
  • sponsor
    Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Updated on 2 December 2022


This study is open label, with one arm only. In this study will be enrolled patients with obesity (BMI more than 30). Aim of the study is to determine the influence (if any) of a very low calorie ketogenic diet (VLCKD) on gut permeability and liver steatosis.

The first objective is to examine the influence of obesity on the prevalence and severity of impaired intestinal permeability and hepatic steatosis.

Intestinal permeability means the ability of the intestinal barrier to block the passage of substances potentially harmful to our body.

The second objective is to evaluate whether a low-calorie and ketogenic dietary intervention, lasting 6 weeks, can change intestinal permeability and hepatic steatosis

Condition Permeability; Increased, NAFLD, Obesity
Treatment Ketogenic diet
Clinical Study IdentifierNCT05477212
SponsorAzienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Last Modified on2 December 2022

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