Dietary Sugar Absorptive Phenotype for Prediction of Weight Loss Outcome

  • End date
    Aug 11, 2024
  • participants needed
  • sponsor
    Mayo Clinic
Updated on 4 October 2022
bariatric surgery
Accepts healthy volunteers


This study is trying to determine whether the success of bariatric surgery can be predicted by evaluating the dietary sugar absorptive characteristics in the small intestine and if there is any gene expression change on the dietary sugar absorptive characteristics.

Condition Obese, Healthy, Bariatric Surgery Candidate
Treatment endoscopic biopsy
Clinical Study IdentifierNCT05408728
SponsorMayo Clinic
Last Modified on4 October 2022


Yes No Not Sure

Inclusion Criteria

Obese patients (BMI ≥ 30) scheduled for BS undergoing standard of care screening EGD, or lean BS-naïve individuals (BMI ≤ 25) subjected to EGD for routine clinical indications as part of standard care

Exclusion Criteria

Adults unable to consent, including non-English speakers
Pregnant women because endoscopy is a risk factor. All patients of childbearing age undergo history as well as urine pregnancy test as a standard of care prior to undergoing endoscopy as the procedure is performed under anesthesia
Subjects with preexisting conditions (e.g., bleeding at the time of the procedure, suspected perforation during the standard-of-care procedure) will be excluded from the study at the time of the endoscopy
Have a contraindication to endoscopy
A history of surgery on the stomach or small intestine
Type 1 diabetes (clinical diagnosis and/or positive glutamic acid decarboxylase antibodies)
Using weight loss medications
Active malignancy within the last 5 years
Clear my responses

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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