Function, Pain, and Alignment Following Knee Replacement for the Treatment of Osteoarthritis

  • End date
    Jan 31, 2024
  • participants needed
  • sponsor
    North York General Hospital
Updated on 4 October 2022


There are many factors that can influence patient satisfaction and patient related outcomes following total knee replacement including the surgical alignment of the joint components. Historically, total knee replacements have been performed with an aim aiming to achieve neutral alignment or a mechanical weight axis in the lower extremity . However, only 0.1 % of the population have a pre-surgical anatomical neutral alignment, and therefore the constitutional anatomy of the patient is neglected. There is a growing trend to return patients back their anatomical constitutional alignment after a knee replacement, referred to as Kinematic Alignment using robotics. The aim of this randomized controlled trial is to examine how mechanical alignment and kinematic alignment impacts function, pain, mood and fatigue following TKR for the treatment of osteoarthritis. Outcomes will be measured at 6 week, 6 months, 1 year and 2 years after surgery.

Condition Knee Replacement, Total, Pain, Postoperative, Functional Independence
Treatment total knee replacement
Clinical Study IdentifierNCT05490186
SponsorNorth York General Hospital
Last Modified on4 October 2022


Yes No Not Sure

Inclusion Criteria

undergoing unilateral TKR for the treatment of osteoarthritis
between the age of 18 and 85 years of age
able to read, speak and understand English, have a telephone
are able to provide consent

Exclusion Criteria

enrolled in another study, are
undergoing revision surgery or bilateral surgery, and are
over the age of 85 years. Patients will also be excluded if they
have a cognitive impairment (as indicated in the medical record) affecting their ability to comprehend the questions being asked
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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