Liquid Biopsy for Early Non-small Lung Cancer Detection

  • End date
    May 31, 2023
  • participants needed
  • sponsor
    University of Arizona
Updated on 4 October 2022
liquid biopsy
lung carcinoma
small lung
Accepts healthy volunteers


This clinical trial will assess the performance of a liquid biopsy assay to identify cancer in indeterminant pulmonary nodules identified by CT screening of high-risk individuals and evaluate the capability of the liquid biopsy assay to monitor response to surgical resection.


This clinical study examines the feasibility of a liquid biopsy methylation assay to detect non-small lung cancer. First, the investigators will apply their liquid biopsy assay to screen for lung cancer in indeterminate pulmonary nodules suspicious for cancer. Second, the investigators will assess the utility of liquid biopsy to assess tumor dynamics after surgical resection with curative intent. Third, the investigators will assess the presence or absence of this methylation assay in healthy normal persons without a history of lung cancer.

Condition Non Small-cell Lung Cancer
Treatment Liquid biopsy for aberrant DNA methylation analysis - Indeterminate pulmonary nodule, Liquid biopsy for aberrant DNA methylation analysis - Known lung cancer for surgical resection, Liquid biopsy for aberrant DNA methylation analysis - Healthy volunteer
Clinical Study IdentifierNCT05462795
SponsorUniversity of Arizona
Last Modified on4 October 2022


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