Taiwan Associated Genetic and Nongenetic Small Vessel Disease (TAG-SVD)

  • End date
    Dec 31, 2026
  • participants needed
  • sponsor
    National Taiwan University Hospital
Updated on 10 August 2022
Accepts healthy volunteers


The TAG-SVD enrolled patients with clinical and neuroimaging features of cerebral small vessel disease (CSVD). All enrolled patients will receive next-generation sequence (NGS) with probes designed to target five candidate CSVD genes, and patients will be divided into genetic or non-genetic groups accordingly. Their clinical features and outcome will be followed for at least 2 years.

Condition Cerebral Small Vessel Diseases, Cadasil, HTRA1-Related Autosomal Dominant Cerebral Angiopathy, COL4A1-Related Brain Small Vessel Disease With Haemorrhage, Fabry Disease, Magnetic Resonance Imaging, Next-generation Sequencing, Stroke
Treatment MRI
Clinical Study IdentifierNCT05473637
SponsorNational Taiwan University Hospital
Last Modified on10 August 2022


Yes No Not Sure

Inclusion Criteria

Participants must have at least one of the following symptoms/signs or history
stroke (especially small vessel occlusion type of ischaemic stroke, spontaneous ICH or young stroke)
cognitive impairment or dementia
gait disturbance
parkinsonism (especially vascular parkinsonism features)
headache (especially migraine)
positive family history of hereditary CSVD
MRI evidence of CSVD (MRI may be done for other reasons), including mild to moderate white matter hyper intensity, any lacune, or any cerebral microbleed

Exclusion Criteria

MRI evidence of CSVD due to other inflammatory, malignancy, or structural lesions
patients or family members not willing to sign informed consent
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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