Treatment of Peripheral Neuropathic Pain (BrainStim)

  • STATUS
    Recruiting
  • End date
    Feb 1, 2027
  • participants needed
    16
  • sponsor
    Oslo University Hospital
Updated on 10 August 2022
chronic pain
polyneuropathy
neuralgia
radiculopathy
peripheral neuropathic pain
nerve damage

Summary

Peripheral neuropathic pain is a disabling chronic pain condition that is difficult to treat. Repetitive transcranial magnetic stimulation (rTMS) to the motor cortex is a treatment method with growing evidence in its ability to alleviate neuropathic pain. This also applies to new deep rTMS coils which permits stimulation of larger cortical areas and with deeper penetration. The aim of this study is to investigate the analgesic efficacy of 5 days of deep rTMS compared to sham stimulation. We will also assess effects of deep rTMS on sleep, psychological fatctors, everyday functioning, and executive functioning.

Details
Condition Neuropathic Pain
Treatment Repetitive transcranial magnetic stimulation
Clinical Study IdentifierNCT05488808
SponsorOslo University Hospital
Last Modified on10 August 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

-80 years of age
Peripheral neuropathic pain related to postherpetic neuralgia, peripheral nerve injury, limb amputation, polyneuropathy or radiculopathy, fulfilling the criteria for probable or definite neuropathic pain (Finnerup et al. 2016)
Usual pain intensity at least 4/10 over the past 24 hrs using the numerical scale of the BPI at screening
Daily pain
Pain for at least 3 months
Stable pharmacological treatment for pain or no pharmaceutical treatment at least 1 month prior to inclusion participation
Ability to follow throughout the whole duration of the study

Exclusion Criteria

atients with phantom limb pain after limb amputation
Any clinically significant or unstable medical or psychiatric disorder
Subjects protected by law (guardianship or tutelage measure)
History of or current substance abuse (alcohol, drugs)
Pending litigation
Contraindication to rTMS (past severe head trauma, history of epilepsy or ongoing epilepsy, active cerebral tumour, past neurosurgical intervention, intracranial hypertension, implanted devices not compatible such as cardiac pacemaker and neurostimulator, cochlear implants, pregnancy or lactation. All women of childbearing age will be required to have negative pregnancy test at inclusion and to be using contraception)
Pain conditions more severe than peripheral neuropathic pain
Inability to understand the protocol or to fill out the forms
Other ongoing research protocol or recent past protocol within one month before the inclusion
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact

site

0/250

Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider

Loading...

Browse trials for

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 

 • 

Private

Reply by • Private
Loading...

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.
Loading...

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note