Early Antiplatelet for Minor Stroke Following Thrombolysis (EAST)

  • End date
    Jul 28, 2024
  • participants needed
  • sponsor
    General Hospital of Shenyang Military Region
Updated on 4 October 2022


The current guideline recommends to give antithrombotic treatment 24 hours after intravenous thrombolysis in acute ischemic stroke. However, early neurological deterioration will occur in some patients due to no antithrombotic treatment, which is closely associated with poor outcome. The current trial aims to investigate the effectiveness and safety of early antithrombotic treatment after intravenous thrombolysis in minor stroke.

Condition Ischemic Stroke
Treatment Aspirin 100mg; Clopidogrel 300mg
Clinical Study IdentifierNCT05193071
SponsorGeneral Hospital of Shenyang Military Region
Last Modified on4 October 2022


Yes No Not Sure

Inclusion Criteria

Age ≥ 18 years old
Acute ischemic stroke patients who received intravenous thrombolysis within 4.5 hours of onset
NIHSS ≤ 5 within 6 hours after the end of intravenous thrombolysis, and no bleeding transformation was found in head CT examination
Premorbid mRS ≤ 1
Signed informed consent

Exclusion Criteria

Premorbid mRS≥2
Uncontrolled severe hypertension (systolic pressure >180 mmHg or diastolic pressure >110 mmHg after drug treatment)
Antithrombotic treatment within 24 hours before randomization
Significant dysphagia and inability to take the experimental drug orally
Allergy or contraindication to study drugs
Comorbidity with any serious diseases and life expectancy is less than half a year
Participating in other clinical trials within three months
Patients not suitable for this clinical study considered by researcher
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