Efficacy of Acupuncture at Acupoints Group Around the Base of Skull for Post-Stroke Depression

  • End date
    Oct 25, 2024
  • participants needed
  • sponsor
    China Academy of Chinese Medical Sciences
Updated on 4 October 2022


The objective of this trial is to evaluate the efficacy and safety of electroacupuncture at acupoints group around the base of skull for post-stroke depression.


98 eligible participants with post-stroke depression will be recruited and randomly assigned to the experimental group and the control group in a ratio of 1:1. Participants in both groups will receive electroacupuncture or placebo acupuncture treatment at acupoints group around the base of skull 3 times a week for 4 weeks, and followed up for 24 weeks.

Condition Post-stroke Depression
Treatment Electroacupuncture, Sham acupuncture
Clinical Study IdentifierNCT05310175
SponsorChina Academy of Chinese Medical Sciences
Last Modified on4 October 2022


Yes No Not Sure

Inclusion Criteria

Conforming to the criteria for the diagnosis of PSD recommended by the "Chinese Expert Consensus on Clinical Practice of Post-Stroke Depression
Aged 40 to 80 years old
The score of HDRS-24 item scale is more than 8 points and less than 35 points, that is, mild to moderate depression
Has not received antidepressant treatment or has been discontinued for more than 2 weeks before entering treatment, and has not participated in other ongoing clinical trials

Exclusion Criteria

Subjects with history of mental illness or family history of mental illness
Subjects with severe heart, liver, kidney, hematopoietic system, endocrine and immune system diseases
Subjects with dementia, aphasia, cognitive dysfunction or unable to cooperate with examination and treatment
Subjects installed with the cardiac pacemaker
Pregnant or lactating patients
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