The Role of Remazolam in Reducing the Incidence of Postoperative Delirium in Elderly Patients

  • STATUS
    Recruiting
  • days left to enroll
    26
  • participants needed
    130
  • sponsor
    Fang Jun
Updated on 4 October 2022

Summary

This study is a prospective, randomized, controlled trial.The selected patients were randomly divided into remazolam general anesthesia group and propofol + midazolam general anesthesia control group according to computer randomization method. There were 65 patients in each group. Remazolam general anesthesia group (R group): Remazolam 0.4 mg/kg for rapid induction of loss of consciousness for anesthesia induction and 1 mg/kg/h for maintenance. Propofol + midazolam general anesthesia control group (group P): propofol 1.5 mg/kg + midazolam 0.05 mg/kg slow intravenous push until the patient's consciousness disappeared, then propofol 4-8 mg/kg/h Anesthesia was maintained. Except for different sedative drugs, the analgesic and muscle relaxant medication regimens were the same between the two groups. In the study, the application of inhaled anesthetics, other benzodiazepines and anticholinergic drugs was restricted, and the mean arterial pressure during the operation was kept above 60 mmHg to avoid perioperative hypotension, hypoxemia, and hypercapnia. Warm measures were used to maintain the patient's intraoperative body temperature above 36.0 °C. POD assessment was performed on the day before surgery and on days 1-7 after surgery.

Details
Condition Postoperative Delirium
Treatment Propofol, Midazolam, remazolam
Clinical Study IdentifierNCT05466279
SponsorFang Jun
Last Modified on4 October 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Elderly patients with limited abdominal tumor surgery (age ≥65 years)
ASA classification I-III

Exclusion Criteria

Refusing to participate in the study
Patients with severe arrhythmia or cardiac dysfunction (EF<35%)
A clear history of neurological and psychiatric disorders before surgery or long-term use of sedatives or antidepressants
History of alcoholism or drug dependence
History of brain surgery or trauma
Severe vision or hearing impairment
Inability to cooperate with the completion of cognitive function tests
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