At the Heart of the Matter - Speckle Tracking Echocardiography in Lupus Mothers and Their Offspring

  • End date
    Sep 30, 2023
  • participants needed
  • sponsor
    Evelyne Vinet
Updated on 4 October 2022


Women with systemic lupus erythematosus (SLE) have a high risk of placenta-mediated complications, which can lead to substantial cardiac morbidities in affected women and their offspring. In addition, maternal autoantibodies, which are actively transferred across the pla-centa during pregnancy, can affect the cardiovascular health of SLE offspring. Hydroxychloroquine (HCQ) is effective in preventing adverse pregnancy outcomes in SLE and might be beneficial in preventing fetal cardiovascular damage mediated by maternal autoantibodies. However, there are concerns that HCQ might cause maternal and neonatal cardiac toxicity. A novel imaging technique (i.e. speckle tracking echocardiography), which allows early identification of cardiac dysfunction, has proven superior to any other in assessing cardiac function in mothers and neonates experiencing placenta-mediated complications and in identifying drug cardiotoxicity. Yet, there has been no study using speckle tracking echocardiography to evaluate the cardiovascular health of pregnant SLE women and their offspring, as well as the potential adverse cardiac effect of HCQ. Moreover, due to unavailability of assays, HCQ dosing in SLE is generally done blindly, without checking drug levels. To fill these key knowledge gaps, we aim to: 1) assess the impact of placenta-mediated complica-tions on maternal and neonatal cardiac function, 2) evaluate if HCQ exposure (as measured by whole-blood levels) is associated with maternal and neonatal outcomes including cardiac toxicity, and 3) determine the effect of maternal autoantibodies on neonatal cardiac function. Ultimately, our proposal will help optimize reproductive and cardiovascular outcomes in lupus women and their off-spring.

Condition Systemic Lupus Erythematosus, Placenta-mediated Pregnancy Complications, Hydroxychloroquine, Speckle Tracking Echocardiography, Cardiovascular Morbidity, Cardiovascular Diseases, Cardiovascular Complication, Pregnancy Complications
Clinical Study IdentifierNCT05451277
SponsorEvelyne Vinet
Last Modified on4 October 2022


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Inclusion Criteria

Followed at participating sites
English/French speaking
Gestational age up to 17 weeks
Intrauterine singleton pregnancy
Between the ages of 18 and 45 years

Exclusion Criteria

Women with multiple intrauterine or extrauterine pregnancies
Women with prior history of placenta-mediated pregnancy complication
Women with preexisting cardiovascular disease, hypertension, and non-gestational diabetes
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