No-touch Radiofrequency Ablation for Recurrent Hepatocellular Carcinoma After Locoregional Treatment Using Combined Energy Delivery Mode and Triple Cooled-Wet Electrodes

  • End date
    Jul 30, 2023
  • participants needed
  • sponsor
    Seoul National University Hospital
Updated on 23 October 2022


To evaluate local tumor progression rate at 12 months after no-touch percutaneous radiofrequency ablation using combined energy delivery mode and triple cooled electrodes

Condition Recurrent Hepatocellular Cancer, Chronic Liver Disease and Cirrhosis
Treatment Radiofrequency ablation using combined bipolar and monopolar energy deliver with Triple Cooled-Wet electrodes
Clinical Study IdentifierNCT05449873
SponsorSeoul National University Hospital
Last Modified on23 October 2022


Yes No Not Sure

Inclusion Criteria

Child-Pugh Class A or B
chronic hepatitis B or chronic hepatitis C or liver cirrhosis
presence of recurrent hepatocellular carcinoma (HCC) after locoregional treatment confirmed by pathology or imaging studies including contrast enhanced computed tomography (CT) or magnetic resonance imaging (MRI) according to Liver Imaging Reporting and Data System (LI-RADS) v2018
single lesion less than or equal to 5 cm, or up to 3 lesions, each greater than less than or equal to 3 cm at the time of locoregional treatment

Exclusion Criteria

number of recurrent HCCs, equal or more than 3
largest recurrent HCC size over 3 cm
presence of vascular invasion by HCC
platelet count less than 40,000 per mm3 or International Normalized Ratio (INR) prolongation over 50%
presence of extrahepatic metastasis
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