Preventing Cognitive Decline

  • End date
    Feb 28, 2023
  • participants needed
  • sponsor
    Arizona State University
Updated on 4 October 2022
Accepts healthy volunteers


The study aims to understand the mechanisms and training effects of evidence-based body-mind training on improving cognitive performance and preventing cognitive decline.


Subjective cognitive decline (SCD), the self-reported perception of memory or cognitive problems, is a risk factor for the cognitive decline and development of Alzheimer's (AD) and often happens in midlife. Recently, few mind-body interventions have suggested promising effects in preventing cognitive decline. However, these interventions often require longer training time (months to years) to achieve modest benefits, making them less optimal for rapidly learning and achieving desirable outcomes. One mechanism for cognitive decline and AD may involve deficits in self-control networks, and autonomic nervous system (ANS) and these deficits can be ameliorated through body-mind interventions. This study aims to investigate the modulation effects of a novel body-mind intervention on SCD using an evidence-based preventive intervention - integrative body-mind training (IBMT).

Condition Cognitive Decline
Treatment Health education, IBMT mindfulness
Clinical Study IdentifierNCT05446909
SponsorArizona State University
Last Modified on4 October 2022


Yes No Not Sure

Inclusion Criteria

Able to read/understand English
Normal performance using standardized cognitive tests
Self-reported decline in cognitive capacity such as memory loss
Eligible for non-invasive fMRI
Willing to be randomized
Free of any severe psychiatric diagnoses or medication that may affect participation

Exclusion Criteria

Medical disorders or medications that affect the central and autonomic nervous system; or a positive pregnancy test result (females)
Unable to provide consent or understand study procedures due to mental illness or cognitive limitations
Previous meditation experiences
Evidence of illicit drug use
Participants for blood draws weigh less than 110 lbs
Metal or metallic materials in the body such as pacemaker
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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