Effect of S-ketamine in Cesarean Section Combined Anesthesia

  • days left to enroll
  • participants needed
  • sponsor
    The Second Affiliated Hospital of Chongqing Medical University
Updated on 7 October 2022
postoperative pain
pain relieving


To compare the anti-hyperalgesia effect between S-ketamine with placebo for Maternal receiving elective Cesarean Section under Combined spinal and epidural analgesia.

Based on this study the investigators intend to verify the role and potential mechanism of S-ketamine combined anesthesia in alleviating hyperalgesia after cesarean section, prove that it can reduce hyperalgesia and postoperative pain. explore the role of S-ketamine in alleviating postoperative hyperalgesia in different PCA ways and explore the safety of S-ketamine in the perilactation

Condition Postoperative Pain
Treatment S-ketamine
Clinical Study IdentifierNCT05414006
SponsorThe Second Affiliated Hospital of Chongqing Medical University
Last Modified on7 October 2022


Yes No Not Sure

Inclusion Criteria

ASA status I-III
Age 20 to 45
-42 weeks gestation
undergo elective cesarean section with subarachnoid anesthesia
participate in this study and sign informed consent

Exclusion Criteria

Patients with contraindications for cesarean section
Patients with contraindications of combined spinal and epidural anesthesia
Patients with severe systemic disease
Alcoholism and long-term use of anti-inflammatory and analgesic drugs
Patients who were unable to cooperate or refused to participate in the trial
Patients with contraindications to esketamine and hydromorphone
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