Remimazolam and Propofol Anesthesia in Elderly Patients

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    Ajou University School of Medicine
Updated on 4 October 2022


Remimazolam is a recently developed ultra-short agonist acting at the benzodiazepine binding site of the gamma-aminobutyric acid (GABA)A receptor. Remimazolam has a combination of the hemodynamic stability of benzodiazepines and the advantages of propofol, such as rapid onset, short duration of action, and improved controllability.

A recent study showed that the efficacy of two induction doses of remimazolam (6 and 12 mg/kg/h) as a sedative for general anesthesia was not inferior to propofol (2.0-2.5 mg/kg), and hemodynamically more stable. On the other hand, a study on the emergence time and quality between propofol and remimazolam showed inconsistent results.

The purpose of this study is to compare remimazolam to propofol on the intraoperative hemodynamic changes and recovery profiles, when used in combination with remifentanil in elderly patients undergoing general anesthesia.

Condition Hemodynamics
Treatment Propofol, Remimazolam Besylate 6 mg/kg/hr, Remimazolam Besylate 12 mg/kg/hr
Clinical Study IdentifierNCT05201300
SponsorAjou University School of Medicine
Last Modified on4 October 2022


Yes No Not Sure

Inclusion Criteria

ASA I, II patients over 65 years old undergoing general anesthesia

Exclusion Criteria

cardiac surgery
liver surgery
uncontrolled hypertension
bronchial asthma
body mass index ≥ 30 kg/m2
severe heart, liver, kidney disease
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