Effect of Remote Ischemic Preconditioning on Cerebral Circulation Time in Patients With Severe Carotid Artery Stenosis (RIP-CCT)

  • End date
    Jun 28, 2023
  • participants needed
  • sponsor
    General Hospital of Shenyang Military Region
Updated on 4 October 2022
carotid artery stenosis


Cerebral circulation time in patients with severe carotid artery stenosis was found to be associated with hyperperfusion syndrome. Remote ischemic preconditioning can change the ability of cerebral autoregulation. The prospective, randomized controlled, blind outcome evaluation, multi-center study aimed to investigate the effect of remote ischemic preconditioning on cerebral circulation time in patients with severe carotid artery stenosis.

Condition Carotid Artery Stenosis
Treatment Remote ischemic preconditioning
Clinical Study IdentifierNCT05451030
SponsorGeneral Hospital of Shenyang Military Region
Last Modified on4 October 2022


Yes No Not Sure

Inclusion Criteria

age 18 years or older, regardless of gender
patients with severe carotid stenosis eligible for stenting (70-99% stenosis confirmed by DSA)
non-responsible vessel stenosis <50% if bilateral carotid stenosis or combined posterior circulation stenosis is present
first DSA suggestive of ≥ 0.8 seconds difference (CCT on the affected side - CCT on the healthy side)
baseline modified Rankin Scale (mRS) ≤ 2 points
signed the informed consent form

Exclusion Criteria

baseline mRS ≥ 3 points
severe long-segment calcification of the carotid artery, severe distortion of aortic arch branches, anatomical variation of the aortic arch, and etc, which are not suitable for stenting
spontaneous intracranial hemorrhage within 12 months
previous severe stroke or myocardial infarction within 3 months
active bleeding and coagulation disorders, which is contraindication to heparin and antiplatelet agents
a large intracranial aneurysm that cannot be treated simultaneously
severe insufficiency of vital organs such as the heart, lungs, liver and kidneys, or malignant tumors with an expected survival cycle of less than six months
total occlusion of carotid artery without obvious cerebral ischemic symptoms
unable to tolerate anesthesia
severe dementia
uncontrolled hypertension
allergy to contrast media
being involved in studies with other drugs or instruments, etc
contraindications to remote ischemic preconditioning, such as those with more severe soft tissue injuries, fractures or vascular injuries in the upper extremity, or peripheral vascular lesions in the distal upper extremity
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