Maternal Risk Factors for Autism Spectrum Disorders: A Case-Control Approach

  • STATUS
    Recruiting
  • End date
    Jun 15, 2023
  • participants needed
    180
  • sponsor
    Walden University
Updated on 20 July 2022
Investigator
Michael Haniff
Primary Contact
Walden University (5.2 mi away) Contact
dietary supplementation
folate
autism spectrum disorders
Accepts healthy volunteers

Summary

New research suggests that about 1 in 8 children may be diagnosed with an autism spectrum disorder (ASD) in the United States. This could be due to several reasons which remain unknown. This study invites mothers who have given birth to children in the United States to share their experiences with diet and supplementation during pregnancy. The purpose of this study is to understand the role of a mother's diet, social standing, and supplementation with folate or folic acid may have on her child's future development of autism. Comparisons will be made between mothers of children who have a child with an official ASD diagnosis from a clinician to mothers of children without an ASD diagnosis. Findings from this study can be used to help identify risk factors for ASD risk.

Description

Autism spectrum disorders (ASD) are a broad range of conditions characterized by social skills, repetitive behaviors, speech, and nonverbal communication challenges. Current prevalence estimates assert that 2.3% of children aged eight years or older live with an ASD, an increase from 1.5% in 2012. Estimates suggest that 1 in 44 children will be diagnosed with ASD. A child diagnosed on the spectrum faces several challenges and may require support from a caregiver, possibly across the lifespan. ASD etiology remains elusive, but research suggests there may be a link to genetic, environmental, and dietary risk factors while in-utero.

Further evidence suggests a folate/folic acid link during the peri-conceptual period. Prior folate/folic acid studies suggest a U-shaped relationship between maternal multivitamin supplementation. High maternal plasma folate and B12 levels are associated with the risk of ASD.

This study aims to apply a case-control approach to understand the role of folate/folic overor under-supplementation, maternal sociodemographics, and diet during pregnancy on ASD risk.

Details
Condition Autism, Autism Spectrum Disorder, Autistic Disorder, Pregnancy Related, Diet, Healthy, Diet; Deficiency, Folate Deficiency, Folic Acid Deficiency, Folic Acid Overdose
Treatment Survey
Clinical Study IdentifierNCT05453708
SponsorWalden University
Last Modified on20 July 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Mothers 18 years or older with a child aged 3-12 years who have an official ASD diagnosis from a clinician
Mothers 18 years or older of children aged 3-12 years who do not have an ASD diagnosis so comparisons can be made between groups

Exclusion Criteria

Mothers outside of the United States
Mothers less than 18 years of age
Mothers who have not given birth to their child or who used a surrogate
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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