Assessment Micro-anatomy of the Menisci and Cartilage After Isolated Acute ACL Injury With MRI at 7T
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- STATUS
- Recruiting
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- End date
- Apr 30, 2023
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- participants needed
- 200
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- sponsor
- Balgrist University Hospital
Summary
There is an ongoing debate regarding the optimal treatment strategy in patients suffering from an acute ACL rupture. Some authors suggest that a non-operative treatment with neuromusculoskeletal rehabilitation program provides sufficient stability and effective recovery after acute injury to the ACL. Others advocate early ACL reconstruction as a first-line treatment for almost all of these patients to reduce the risk of joint instability, thereby preventing secondary joint damage such as meniscal injuries and osteoarthritis. Nevertheless, there is no evidence that an ACL reconstruction might actually prevent the development of knee osteoarthritis. However, concomitant meniscal injuries, either at the time of the ACL injury or secondary to the ACL injury, significantly increase the risk for secondary knee osteoarthritis. Therefore, the treatment strategy of ACL injuries is strongly influenced by the presence of concomitant meniscal injuries on initial magnetic resonance imaging (MRI).
In order to gain higher spatial resolution and faster image acquisition, a clear trend toward higher field strength MRI exists. However, there is still a paucity of data in the current literature, whether these improvements actually benefit patients and treating physicians.
Again and again, meniscal injuries occur in the course after isolated ACL ruptures, where the question arises whether these injuries occurred during the initial trauma or due to the ruptured ACL.
Thus, 200 patients with an acute, presumably isolated ACL rupture who have received a standard MRI will additionally be examined with an ultrahigh-field MRI (T7). Therefore, the primary objective of the current study was to evaluate the potential utility of ultrahigh-field MRI (T7) in detecting occult meniscal tears associated with presumed isolated acute ACL injuries compared with high-field MRI (T3 or less). The secondary objective was to evaluate the influence of meniscal tear location and meniscal tear pattern on the sensitivity of high-field MRI compared with ultrahigh-field MRI in detecting meniscal tears.
Description
Study population The investigator set the sample size to 200 patients.
Primary outcome
- Diagnostic accuracy of ultrahigh field MRI (T7) compared to high field MRI (T3 or less) for detection of meniscal injuries associated with acute ACL injury Secondary outcome
- Influence of 1) Location of injury and 2) meniscal tear pattern (modified WORMS18,19) on the sensitivity of high field MRI compared to ultrahigh field MRI for detection of meniscal tears
Details
| Condition | Meniscus Lesion, Cartilage Injury, ACL Injury |
|---|---|
| Treatment | Ultrahigh Field MRI at 7T |
| Clinical Study Identifier | NCT05433012 |
| Sponsor | Balgrist University Hospital |
| Last Modified on | 4 October 2022 |
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