Study to Assess Allogeneic Anti-CD38 A2 Dimeric Antigen Receptor T Cells in Relapsed or Refractory Multiple Myeloma
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- STATUS
- Recruiting
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- End date
- Dec 22, 2024
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- participants needed
- 54
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- sponsor
- Sorrento Therapeutics, Inc.
Summary
This is a phase 1b, open-label, dose-escalation study of STI-1492 administered by a single intravenous infusion in subjects with relapsed or refractory multiple myeloma.
Description
This is a phase 1b, open-label, multicenter, dose-escalation study of STI-1492 administered by a single intravenous infusion in subjects with relapsed or refractory multiple myeloma.
The study will determine the MTD and RP2D, assessing safety and preliminary efficacy using a conventional 3+3 study design with two design stages, an ascending dose stage followed by an expansion study.
Patients will be enrolled sequentially within each cohort and between cohorts during the dose escalation portion of the study with the staggered intervals of at least 28 days. Only one patient will be allowed to receive study treatment at any time through the end of the staggering period before the next subject may begin study treatment.
Details
| Condition | Multiple Myeloma |
|---|---|
| Treatment | STI-1492 |
| Clinical Study Identifier | NCT05007418 |
| Sponsor | Sorrento Therapeutics, Inc. |
| Last Modified on | 7 October 2022 |
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