Bilateral TAP and RS Blocks Using Liposomal Bupivacaine/Bupivacaine vs. Regular Bupivacaine in Laparoscopic Colectomy (TAPLIP)

  • STATUS
    Recruiting
  • End date
    Feb 10, 2026
  • participants needed
    114
  • sponsor
    Hartford Hospital
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Updated on 4 October 2022
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Summary

This study will be a single center, prospective triple blinded randomized controlled study, comparing the use of liposomal bupivacaine (Exparel) to regular bupivacaine with adjuncts in bilateral mid-abdominal transverse abdominis plane (TAP) blocks for patients undergoing laparoscopic colectomy procedures.

Details
Condition Bowel Disease
Treatment Bupivacaine HCl, Liposomal Bupivicaine/Bupivacaine Admixture
Clinical Study IdentifierNCT05224089
SponsorHartford Hospital
Last Modified on4 October 2022

Eligibility

 Yes No Not Sure

Inclusion Criteria

Patients scheduled for elective laparoscopic colectomy surgery to be performed by one of the 4 colorectal surgeons in the study
English speaking patients
Patients with American Society of Anesthesiology (ASA) physical status score I- IV

Exclusion Criteria

Emergency laparoscopic colectomy surgery
Patients with distant metastatic cancers (e.g. bone, lung, brain)
Scheduled for multi organs resection surgery in addition to colectomy
Patients with contraindications to TAP or RS blocks including but not limited to anatomical abnormality, previous surgical intervention that limits or prevents receiving bilateral TAP blocks (e.g. surgical mesh at the site of TAP or RS block), or infection at the injection site
Current colostomies
History of allergy to local anesthetics
Coagulopathy or coagulation disorder. Also patients who are receiving antithrombotic medications as a contraindication to receiving single shot peripheral nerve blockade as per the most recent American Society of Regional Anesthesiology (ASRA) guidelines.16
Weight < 40 kg, as 40 mL of Bupivacaine 0.25%, or combination of 20 mL of bupivacaine 0.25% with 20 mL of liposomal bupivacaine is greater than the maximal dose allowed, given concern for local anesthetic toxicity
Patients who take long acting opioid medication, or on continuous opioid > 50 MME per day for at least 30 days within 90 days prior to surgery. Also patients who have chronic pain syndrome with a recent preoperative consultation to the chronic pain service
Patients with current substance abuse, or history of substance abuse within 3 months, this includes any illicit drugs or excessive alcohol consumption as defined 4 or more drinks per day or 8 or more drinks per week for women and 5 or more drinks per day or 15 or more drinks per week for men.15
Pregnant, nursing, or planning to become pregnant during the study or within 1 month postoperatively
Refusal or lack of providing the study consent
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