Chronic Heart Failure - COngestion eValuation (CHF-COV)

  • End date
    Jun 14, 2029
  • participants needed
  • sponsor
    Pr. Nicolas GIRERD
Updated on 9 July 2022


Heart failure (HF) is a significant cause of death and the leading cause of hospitalization in patients over 65 years of age. Congestion is the main source of symptoms and the leading cause of hospitalization for HF. Furthermore, congestive signs identified in asymptomatic patients are associated with the risk of developing symptomatic HF. The literature supports a multi-modality / integrative evaluation of congestion, combining clinical examination, laboratory results and ultrasound evaluation.

The main objective of the CHF-COV study is to identify congestion markers (clinical, biological and ultrasound) in day hospitalization for chronic HF monitoring that are associated with the risk of all-cause death or hospitalization for acute HF within 24 months after day hospitalization.

Condition Chronic Heart Failure
Treatment Telephone follow-up, Clinical examination centered on congestion, Blood sample retrieved for biological assessment and biobanking, Cardiac, pulmonary, peritoneal, jugular and renal venous Doppler ultrasounds
Clinical Study IdentifierNCT05089149
SponsorPr. Nicolas GIRERD
Last Modified on9 July 2022


Yes No Not Sure

Inclusion Criteria

Patients with chronic acute heart failure admitted in hospital for scheduled day hospitalization
Age ≥18 years
Patients having received complete information regarding the study design and having signed their informed consent form
Patient affiliated to or beneficiary of a social security scheme

Exclusion Criteria

Comorbidity for which the life expectancy is ≤ 3 months
Dialysis patient (peritoneal dialysis or hemodialysis) or patients with glomerular filtration rate <15 ml/min/m2 at inclusion
History of lobectomy or pneumonectomy lung surgery
Severe pulmonary or pleural pathology preventing reliable acquisition of lung ultrasound images: severe emphysema, chronic pleurisy, pulmonary fibrosis, etc
Pregnant woman, parturient or nursing mother
Adult person subject to a legal protection measure (guardianship, curatorship, safeguard of justice)
Adult person who is unable to give consent
Person deprived of liberty by a judicial or administrative decision
Person subject to psychiatric care pursuant to Articles L. 3212-1 and L. 3213-1 of the Public Health Code
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