Natriuretic Peptides as a Prognostic and Risk Stratification Tool in Assessment of Valvular Heart Disease

  • days left to enroll
  • participants needed
  • sponsor
    Assiut University
Updated on 9 July 2022
Accepts healthy volunteers


NPs can be used To detect subset of asymptomatic with subtle LV dysfunction for further evaluation and earlier referral for intervention and its correlation with echocardiographic finding.


Each patient included in the study will undergo:

  1. History taking:

Analysis of patient symptoms and signs (dyspnea , orthopnea , Paroxysmal nocturnal dyspnea, lower limb edema , tachypalpitations,…etc )

2. Clinical examination:

  • Detecion of each patient body weight , height , calculation of BMI.
  • General examination for detection of signs of Heart failure (raised JVP , lower limb edema, ..etc)
  • Examination to respiratory system
  • Auscultation of the heart for detection of valvular affection before echocardiography

Laboratory investigations:

Urea and creatinine . b) ECG : for exclusion of atrial fibrillation and other arrythmias. 2D Transthorathic Echocardiography (TTE) Evaluation of valve morphology and thickness , gradients and valve area , regurgitant lesions and its severity.

Evaluation of internal cardiac dimensions and function. 5- Natriuretic peptides: as a useful screening tool to differentiate symptomatic and asymptomatic patients.

Condition Valvular Heart Disease Stenosis and Regurgitation
Clinical Study IdentifierNCT05439369
SponsorAssiut University
Last Modified on9 July 2022


Yes No Not Sure

Inclusion Criteria

All patients echocardiographically diagnosed with significant valve lesions. Rheumatic Heart disease with significant but asymptomatic valvular Heart Disease especially (Mitral valve disease )(MS and MR) Gender: male & female

Exclusion Criteria

Cases with increased level of BNP as in
Renal impairment Advanced age and obesity Atrial fibrillation and acute coronary syndromes
Prior lung diseases and acute illness
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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