Effect of Tranexamic Acid on Intraoperative Blood Loss in Patients Undergoing Brain Meningioma Resections: Study Protocol of a Randomised Controlled Trial

  • STATUS
    Recruiting
  • End date
    Jun 30, 2025
  • participants needed
    228
  • sponsor
    Beijing Tiantan Hospital
Updated on 15 September 2022
tranexamic acid

Summary

Intra-operative blood loss of huge meningioma resection patients on average was over 1000ml. Intra-operative massive hemorrhage was associated with longer hospital of stay, higher expense, and higher mortality. Previous studies indicated intra-operative tranexamic acid infusion would decrease blood loss for cardiac, trauma and obstetric procedures. However, limited researches focusing on the effect of tranexamic acid in neurosurgery population, with heterogenous pathologies. The purpose of this study was to investigate the effect of tranexamic acid on intra-operative blood loss in patients undergoing huge meningioma resection.

Details
Condition Tranexamic Acid, Intraoperative Blood Loss, Meningioma
Treatment Placebo, Continous infusion, Single infusion
Clinical Study IdentifierNCT05230381
SponsorBeijing Tiantan Hospital
Last Modified on15 September 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Patients undergoing elective supratentorial meningioma resection with estimated tumor diameter >5cm on brain image
Age between 18-65 years
Obtain written informed consent
American Society of Anaesthesiologist (ASA) physical status Ⅰ to Ⅲ

Exclusion Criteria

Allergic to tranexamic acid
History of thrombotic disease
History of chronic kidney disease
Receiving other anticoagulation or antiplatelet treatment
Refuse to provide written informed consent
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