Effects of Intermittent Theta Burst Stimulation in Addition to Constraint-Induced Movement Therapy in Stroke Patients

  • End date
    May 15, 2024
  • participants needed
  • sponsor
    Istanbul Medeniyet University
Updated on 15 July 2022


In recent studies, it has been reported that intermittent theta-burst stimulation (iTBS) provides additional benefits when applied in adjunct to the rehabilitation in all stages of stroke (acute, subacute, or chronic). In our study, it was aimed to evaluate the effectiveness of iTBS applied in addition to modified constraint-induced movement therapy (mCIMT). By doing so, we intend to increase patient adherence to neurorehabilitation and decrease the cost of rehabilitation.

Condition Stroke, Ischemic
Treatment Rehabilitation (modified constraint-induced movement therapy), non-invasive brain stimulation (intermittent theta-burst stimulation)
Clinical Study IdentifierNCT05308667
SponsorIstanbul Medeniyet University
Last Modified on15 July 2022


Yes No Not Sure

Inclusion Criteria

First time and unilateral stroke
-12 months after the incident
Getting 24 points or more in Mini Mental Status Examination
Being able to stand for 2 minutes without any help by using the upper extremity as a support tool when necessary
Being a low-functioning patient according to the CIMT criteria: a) At least 10 degrees of active wrist extension starting from the angle of full flexion, b) 10 degrees of extension at the metacarpophalangeal and inter-phalangeal joints of at least 2 fingers

Exclusion Criteria

those who score more than 2.5 points on the Motor Activity Log-28 scale
who have severe pain in the upper extremity (5 and above on the Visual Analogue Scale) and spasticity (3 and above on the Modified Ashworth Scale), which may affect the treatment, and
Those who do not have adequate communication skills
Patients who have visual problems
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