Oral Care With Propolis in Pediatric Oncology Patients

  • STATUS
    Recruiting
  • End date
    Dec 1, 2023
  • participants needed
    108
  • sponsor
    Izmir Katip Celebi University
Updated on 11 July 2022

Summary

According to the data from the World Health Organization, approximately 14 million people are diagnosed with cancer every year, and this number is expected to increase further in the next 10 years. Multidisciplinary treatment consisting of chemotherapy, radiotherapy and surgery is applied in childhood cancers. In chemotherapy, the target is cancerous cells, but high doses of chemotherapeutic agents do not have selectivity. Intact tissue cells are also affected by this cytotoxicity. Mucositis develops in the patient, especially as a result of the mucosal cells being affected. Mucositis is defined as damage to the mucosa lining the oral cavity, pharynx, larynx, oesophagus and gastrointestinal tract due to cancer treatment. It is one of the most important side effects of both chemotherapy and radiotherapy. This study is carried out to determine the effectiveness of propolis in preventing the formation of oral mucositis due to multiple use of chemotherapeutic drugs.

Description

According to the data from the World Health Organization, approximately 14 million people are diagnosed with cancer every year, and this number is expected to increase further in the next 10 years. Multidisciplinary treatment consisting of chemotherapy, radiotherapy and surgery is applied in childhood cancers. In chemotherapy, the target is cancerous cells, but high doses of chemotherapeutic agents do not have selectivity. Intact tissue cells are also affected by this cytotoxicity. Mucositis develops in the patient, especially as a result of the mucosal cells being affected. Mucositis is defined as damage to the mucosa lining the oral cavity, pharynx, larynx, oesophagus and gastrointestinal tract due to cancer treatment. It is one of the most important side effects of both chemotherapy and radiotherapy. This study is carried out to determine the effectiveness of propolis in preventing the formation of oral mucositis due to multiple uses of chemotherapeutic drugs.

Details
Condition Oral Mucositis
Treatment Placebo, Propolis
Clinical Study IdentifierNCT05400031
SponsorIzmir Katip Celebi University
Last Modified on11 July 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Volunteering to participate in the study
Receiving chemotherapy treatment for lymphoproliferative malignant disease (leukaemia, lymphoma) or other childhood solid tumour (such as central nervous system tumour, neuroblastoma, osteosarcoma, Ewing sarcoma, rhabdomyosarcoma, hepatoblastoma, germ cell tumours)
Being between the ages of 2-18 (Although there is no harm in using propolis, it is inconvenient for children under the age of 2 to use honey and its by-products due to botulism)
No development of oral mucositis
The child who does not smoke

Exclusion Criteria

The patient does not receive head and neck RT (increases the incidence of oral mucositis by 40%)
The patient is allergic to bee products
Exclusion Criteria and Practices in this Case
Development of an allergic reaction to propolis (Applied oral care protocol is stopped, removed from the sample)
Starting RT
The child's need for MV support
Clear my responses

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