Exploring the Cortical Hemodynamic Response of Excitatory Brain Stimulation: a Pilot Study

    Not Recruiting
  • participants needed
  • sponsor
    The Hong Kong Polytechnic University
Updated on 4 December 2022
Accepts healthy volunteers


Intermittent theta-burst stimulation (iTBS) is a promising treatment for major depressive disorder. However, fewer than 50% of patients show sufficient response. Therefore, the optimal treatment protocol is worth investigating. Recent studies show that the relationship between stimulation intensity and prefrontal hemodynamic response is not linear but in an inverse U-shape by exploring the hemodynamic changes before and after iTBS. Concurrent transcranial magnetic stimulation (TMS)/functional near-infrared spectroscopy (fNIRS) setup allows the investigators to observe the prefrontal hemodynamic response during stimulation.

The aim of this study is to investigate the effects of different intensities on brain activity during and after the stimulation using fNIRS.


Please refer to the full proposal

Condition Healthy
Treatment Intermittent theta-burst stimulation (iTBS)
Clinical Study IdentifierNCT05427552
SponsorThe Hong Kong Polytechnic University
Last Modified on4 December 2022

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