Novel Multimodal Assessment of Practical Judgment Across the Alzheimer's Continuum: Toward a Better Understanding of how to Predict Risk in the Elderly

  • End date
    Jun 1, 2023
  • sponsor
    National Institute On Aging
Updated on 25 July 2022
alzheimer's disease
Accepts healthy volunteers


By the year 2050, as many as 16 million individuals in the U.S. will express symptoms of Alzheimer’s disease (AD). A recent White House Conference on Aging emphasized the need to improve detection of diminished capacity as a means to improve personal safety and prevent financial exploitation and abuse. The purpose of this study is to determine how early, mild changes in practical judgment and problem-solving skills may impact older adults in terms of susceptibility to scam and fraud. Ultimately, by identifying when and how changes in practical judgment occur, the researchers are hoping to help prevent victimization for vulnerable older adults.


This federally funded research study examines how changes in changes in practical judgment and problem-solving skills may impact diverse older adults in terms of susceptibility to scam and fraud. The researchers are currently recruiting individuals aged 60 to 90, with or without cognitive impairment, to better understand the role of cognitive function, brain regions, and genetic factors on susceptibility to scam and fraud victimization. The study involves 2 visits and does not require any follow up visits over time. Eligible participants will undergo a 60-minute brain imaging scan (MRI), paper and pencil based cognitive testing, and genetic testing using saliva sample. Participants must also bring someone who knows them well to the study visit. All study procedures are non-invasive (does not involve any use of injections or IVs) and will be conducted at no cost. Participants will receive compensation for their time. Interested individuals can contact Abigail Zatkalik (study coordinator), by calling 402-836-9826 or by emailing

Condition Alzheimer's Disease, Dementia, Mild Cognitive Impairment, subjective cognitive impairment
Clinical Study IdentifierTX302912
SponsorNational Institute On Aging
Last Modified on25 July 2022


Yes No Not Sure

Inclusion Criteria

-90 years of age
Presence of an informant who has had weekly contact with the participant, either by phone or in person, for at least the last 10-years
Participant is capable of providing written informed consent or assent

Exclusion Criteria

History of persistent and severe mental illness
Diagnosis of any neurological disorder other than the diagnosis for which they are included in the study (e.g., focal stroke detected on imaging, Parkinson’s disease, epilepsy, multiple sclerosis)
History of head trauma with loss of consciousness (LOC) > 5 minutes
History of or ongoing substance use disorder as defined by the DSM-V
History of prior diagnosis of learning disability or Attention Deficit Hyperactivity Disorder as per the DSM-V
Chronic use of medications(s) that affect cognition (>5 years use of daily opiates, anticholinergic agents)
Severe visual or hearing impairments that prevent the participant from undergoing the neuropsychological assessment
Those for whom an informant is not available
Persons with contraindications for MRI
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact


Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Browse trials for

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note