Novel Multimodal Assessment of Practical Judgment Across the Alzheimer's Continuum: Toward a Better Understanding of how to Predict Risk in the Elderly

  • STATUS
    Recruiting
  • End date
    Jun 1, 2023
  • sponsor
    National Institute On Aging
Updated on 25 July 2022
alzheimer's disease
Accepts healthy volunteers

Summary

By the year 2050, as many as 16 million individuals in the U.S. will express symptoms of Alzheimer’s disease (AD). A recent White House Conference on Aging emphasized the need to improve detection of diminished capacity as a means to improve personal safety and prevent financial exploitation and abuse. The purpose of this study is to determine how early, mild changes in practical judgment and problem-solving skills may impact older adults in terms of susceptibility to scam and fraud. Ultimately, by identifying when and how changes in practical judgment occur, the researchers are hoping to help prevent victimization for vulnerable older adults.

Description

This federally funded research study examines how changes in changes in practical judgment and problem-solving skills may impact diverse older adults in terms of susceptibility to scam and fraud. The researchers are currently recruiting individuals aged 60 to 90, with or without cognitive impairment, to better understand the role of cognitive function, brain regions, and genetic factors on susceptibility to scam and fraud victimization. The study involves 2 visits and does not require any follow up visits over time. Eligible participants will undergo a 60-minute brain imaging scan (MRI), paper and pencil based cognitive testing, and genetic testing using saliva sample. Participants must also bring someone who knows them well to the study visit. All study procedures are non-invasive (does not involve any use of injections or IVs) and will be conducted at no cost. Participants will receive compensation for their time. Interested individuals can contact Abigail Zatkalik (study coordinator), by calling 402-836-9826 or by emailing wnl@unmc.edu.

Details
Condition Alzheimer's Disease, Dementia, Mild Cognitive Impairment, subjective cognitive impairment
Clinical Study IdentifierTX302912
SponsorNational Institute On Aging
Last Modified on25 July 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

-90 years of age
Presence of an informant who has had weekly contact with the participant, either by phone or in person, for at least the last 10-years
Participant is capable of providing written informed consent or assent

Exclusion Criteria

History of persistent and severe mental illness
Diagnosis of any neurological disorder other than the diagnosis for which they are included in the study (e.g., focal stroke detected on imaging, Parkinson’s disease, epilepsy, multiple sclerosis)
History of head trauma with loss of consciousness (LOC) > 5 minutes
History of or ongoing substance use disorder as defined by the DSM-V
History of prior diagnosis of learning disability or Attention Deficit Hyperactivity Disorder as per the DSM-V
Chronic use of medications(s) that affect cognition (>5 years use of daily opiates, anticholinergic agents)
Severe visual or hearing impairments that prevent the participant from undergoing the neuropsychological assessment
Those for whom an informant is not available
Persons with contraindications for MRI
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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