The Impact of Metformin on the Outcome of Gouty Arthritis in a Cohort of Egyptian Gouty Patients. (Mets in gout)

  • STATUS
    Recruiting
  • days left to enroll
    60
  • participants needed
    100
  • sponsor
    Menoufia University
Updated on 9 July 2022
arthritis

Summary

Objective

To study the impact of metformin on the outcome of gouty arthritis in a cohort of Egyptian gouty patients, and to evaluate its effect on local joint inflammation, inflammatory cytokines (IL-1β and IL-6), and life quality.

Methods

A prospective randomized, single-blinded parallel randomized control study included 100 patients with active inflammatory gouty arthritis were randomized to receive metformin (1000mg/day) or placebo in addition to the traditional lines of treatment of gout. The clinical and laboratory data of the patients will be analyze at baseline, then after 3, and 6 months, with the assessment of gout disease activity, in addition, serum IL-1β and IL-6, the number of attacks per year, treatment satisfaction, quality of life, and disability index were evaluated at the 6th month from starting metformin and placebo therapy.

Description

Background: Metformin has anti-inflammatory properties, as it suppresses the inflammatory process by down-regulating the transcription factor, nuclear factor kappa B (NF-kB), through AMP-activated protein kinase (AMPK)-dependent and independent pathways.

Objective

To study the impact of metformin on the outcome of gouty arthritis in a cohort of Egyptian gouty patients, and to evaluate its effect on local joint inflammation, inflammatory cytokines (IL-1β and IL-6), and life quality.

Methods

A prospective randomized, single-blinded parallel randomized control study included 100 patients with active inflammatory gouty arthritis were randomized to receive metformin (1000mg/day) or placebo in addition to the traditional lines of treatment of gout. The clinical and laboratory data of the patients will be analyzed at baseline, then after 3, and 6 months, with the assessment of gout disease activity, in addition, serum IL-1β and IL-6, the number of attacks per year, treatment satisfaction, quality of life, and disability index were evaluated at the 6th month from starting metformin and placebo therapy.

Details
Condition Gouty Arthritis
Treatment Placebo, Metformin
Clinical Study IdentifierNCT05332795
SponsorMenoufia University
Last Modified on9 July 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

gouty patients who fulfilled the American College of Rheumatology clinical criteria
gouty patients with active inflammatory arthritis

Exclusion Criteria

Patients with any type of inflammatory arthritis
Patients with systemic disease as diabetes, hypertension
Patients with hyperlipidemia, coronary artery disease
Patients with renal or hepatic insults
pregnant and lactating females
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