Efficacy of PRF Application on Clinical Parameters and GCF Platelet-derived Growth Factor-BB and Periostin Levels

  • STATUS
    Recruiting
  • days left to enroll
    52
  • participants needed
    14
  • sponsor
    University of Baghdad
Updated on 21 July 2022
growth factor
probe
rhpdgf-bb
Accepts healthy volunteers

Summary

Determine the efficacy of the non-invasive application of PRF on periodontal clinical parameters(pocket reduction) and the levels of PDGF-BB and Periostin in the gingival crevicular fluid.

Description

The adjunctive use of PRF with conventional ScRp may improve clinical healing, decrease tissue morbidities such as pain and discomfort, increase patient acceptance, reduce treatment time. Since PRF can be utilized as a safe, natural method to repair tissues at a low cost. Our aim is to evaluate the effectiveness of the non-invasive application of PRF as an adjunct to ScRp in patients with stage III grade B periodontitis through measurements of gingival crevicular fluid levels of PDGF-BB and Periostin before and after treatment and compare it with ScRp alone. A split-mouth procedure will be performed to reduce confounders as possible.

Details
Condition Periodontitis
Treatment Platelet rich fibrin
Clinical Study IdentifierNCT05178771
SponsorUniversity of Baghdad
Last Modified on21 July 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Systemically healthy patients
Patients with periodontitis

Exclusion Criteria

Medical history of systemic disease: diabetes, pregnancy, or lactation
Previous periodontal treatment for the last 6 months
Grade II mobility
Smoker or alcoholic patient
Teeth with untreated caries, endodontic lesions
Symptoms of recent acute illness e.g., COVID-19 will be excluded as well
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