Transcriptomic Responses for the Identification of Pathogens (TRiP)

  • End date
    Jun 7, 2024
  • participants needed
  • sponsor
    University of Sheffield
Updated on 7 July 2022
Accepts healthy volunteers


Acute undifferentiated febrile infection (AUFI) is a common presenting syndrome in low-resource settings and better diagnostics are urgently needed to improve patient management and guide disease prevention interventions. Assessment of the host gene expression response to infection in endemic populations has demonstrated significant promise as a new approach to identifying patients with enteric fever and for potential in differentiating between other causes of AUFI. Signatures identified through new data analytic techniques could be developed into a point-of-care test for use in endemic settings.

In this multisite diagnostic evaluation study we will collect prospective clinical, laboratory and diagnostic data from two endemic settings to evaluate host gene expression signatures for detecting enteric fever and for determining the cause of AUFI in LMIC settings.

Condition Enteric Fever, Acute Febrile Illness, Typhoid, Paratyphoid Fever, Fever
Treatment 5-gene transcription signature
Clinical Study IdentifierNCT04878549
SponsorUniversity of Sheffield
Last Modified on7 July 2022


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