Study of Ipilimumab, Nivolumab, and Cabozantinib in Patients With Cutaneous Melanoma

  • End date
    Jun 27, 2031
  • participants needed
  • sponsor
    Providence Health & Services
Updated on 27 June 2022


The primary objective of this clinical trial is to evaluate the clinical efficacy and progression free survival of the triplet combination of ipilimumab + nivolumab + cabozantinib in patients with anti-PD-1/PD-L1 refractory metastatic cutaneous melanoma.


This is a phase II, single arm, single institution clinical trial. Eligible adults with anti-PD-1 refractory, unresectable/metastatic cutaneous melanoma will be treated with the triplet combination of ipilimumab 1 mg/kg + nivolumab 3 mg/kg every 3 weeks for 4 cycles in addition to cabozantinib 40 mg/day. For cycles 5+, treatment will consist of nivolumab 480 mg IV every 4 weeks in combination with cabozantinib 40 mg/day. The total duration of therapy will be 24 months or until either disease progression or the occurrence of unacceptable drug-related toxicity. Regular tumor assessments should be performed to determine if PD is present.

Condition Refractory Cutaneous Melanoma
Treatment Ipilimumab, Nivolumab, Cabozantinib
Clinical Study IdentifierNCT05200143
SponsorProvidence Health & Services
Last Modified on27 June 2022


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