The purpose of the proposed investigation is to carry out a pilot study of add-on perampanel (Fycompa) in women with perimenstural (C1) catamenial epilepsy. Perampanel, a noncompetitive AMPA receptor antagonist, is uniquely positioned to decrease progesterone receptor mediated excitotoxicity. This mechanism of action would allow a novel use of perampanel as an effective treatment of C1 catamenial epilepsy.
| Condition | Catamenial Epilepsy |
|---|---|
| Treatment | Fycompa, Fycompa with a boost |
| Clinical Study Identifier | NCT05201703 |
| Sponsor | University of Florida |
| Last Modified on | 5 February 2023 |
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