Autologous Testicular Tissue Transplantation

  • STATUS
    Recruiting
  • End date
    Oct 29, 2030
  • participants needed
    5
  • sponsor
    Universitair Ziekenhuis Brussel
Updated on 2 July 2022
remission

Summary

Freezing testicular tissue of prepubertal boys is a method for preserving spermatogonial stem cells (SSCs) in case of imminent gonadotoxic treatment during childhood. In case of total azoospermia in adulthood and presence of a childwish, the investigators intend to perform the first in men autologous testicular tissue transplantation to restore fertility.

Description

Freezing testicular tissue of prepubertal boys is a method for preserving spermatogonial stem cells (SSCs). In 2002, the University hospital in Brussels (UZB) was the first hospital worldwide to offer testicular tissue cryobanking for fertility preservation in boys and ado-lescents. Since then, several other centers in Europe and USA have implemented similar fertility preservation programs. However, up till now, autologous transplantations of cryopreserved testicular tissue have not been performed yet.

As soon as a patient returns to the Centre for Reproductive Medicine at UZB with the request to transplant the preserved testicular tissue, the investigators will first analyse semen and blood. If spermatozoa are found in their semen, men can immediately enroll in standard care for natural conception, intra-uterine insemination (IUI), in-vitro fertilization (IVF) or intra-cytoplasmic injection (ICSI). However, in case no spermatozoa are found in the ejaculate or after performing a testicular biopsy (TESE), the investigators intend to propose and eventually perform autologous testicular tissue transplantation with the primary objective being to restore spermatogenesis and fertility.

Details
Condition Cancer, Sickle Cell Thalassemia, Hematologic Diseases
Treatment Autologous testicular tissue transplantation of prepubertal frozen testicular tissue
Clinical Study IdentifierNCT05414045
SponsorUniversitair Ziekenhuis Brussel
Last Modified on2 July 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

At least 18 years old
Desire to become a parent at the moment of intake
Stable relationship with a female partner and minimal one year cohabiting
Age of female partner < 43 year
Azoospermia on 2 semen analyses
Normal standardised preliminary and preoperative bloodsampling results
Complete remission of the oncological or hematological disease
Approval of the treating oncologist or other specialist in case of non-oncological
disease as reason for the testicular tissue preservation as a child
Risk for presence of malignant cells in testicular tissue is negligible (according to
multidisciplinary assessment)
Presence of SSCs (positive MAGE staining) in one or two of the thawed fragments (If
absence of SSCs in two of the thawed fragments, the case will be discussed
multidisciplinary)
Written informed consent for the transplantation of cryopreserved testicular tissue
and follow-up after the procedure and of children born eventually after this procedure

Exclusion Criteria

Risk for presence of malignant cells in the testicular tissue
Contra-indication for surgery
Contra-indication for pregnancy in the female partner
BMI > 32
Heavy smoking (≥10 cigarettes/day)
Instable psychological condition
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