Clinical Study on Monitoring the Plasma Concentration of Ceftazidime-Avibactam in Critically Ill Patients

  • STATUS
    Recruiting
  • days left to enroll
    3
  • participants needed
    30
  • sponsor
    First Affiliated Hospital of Zhejiang University
Updated on 1 July 2022
severe sepsis

Summary

A observational study is conducting at the First Affiliated Hospital of the Medical College of Zhejiang University from January 1, 2022 to September 30, 2022. Patients with severe sepsis and treatment with Ceftazidime-Avibactam will be enrolled.

Blood samples at 0, 2, 4, 6, and 8 h after the first time and the steady state(5 times) of administration will be collected to detect plasma drug concentrations of ceftazidime avibactam.

Description

We will collect the blood samples at 0, 2, 4, 6, and 8 h after the first time and the steady state(5 times) of administration from the patients receive treatment with Ceftazidime-Avibactam to detect plasma drug concentrations of ceftazidime avibactam.The collected specimens will be stored in a refrigerator at 0-8 °C, centrifuges within 24 hours (4 °C, 4000 r/min, 10 min), and the supernatant will be collected in an EP tube and stored in a -80 °C refrigerator. Ultra-high performance liquid chromatography-mass spectrometry (UPLC-MS/MS) will be used to detect plasma drug concentrations of ceftazidime avibactam. According to the outcomes ,we will analyse the follwing items,(1)T>MIC,(2)Cmax/MIC,(3)AUC/MIC.

Details
Condition Severe Sepsis
Treatment Ceftazidime-avibactam
Clinical Study IdentifierNCT05413343
SponsorFirst Affiliated Hospital of Zhejiang University
Last Modified on1 July 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

(1) Patients with severe sepsis and treated with ceftazidime avibactam,(2) Age ≥ 18
years,(3) The patient or authorized persons agree and sign the informed consent, (4) The
patient's hemoglobin is greater than 70g/l during blood collection

Exclusion Criteria

(1)The length of ICU stay more than 48 hours,(2)The blood sample is hemolysis
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