Diagnosis of Metastatic Tumors on 68Ga-FAPI PET-CT and Radioligand Therapy With 177Lu-EB-FAPI

  • STATUS
    Recruiting
  • End date
    Apr 1, 2023
  • participants needed
    10
  • sponsor
    Peking Union Medical College Hospital
Updated on 15 June 2022

Summary

FAP is a fibroblast activation protein and overexpressed in many tumor tissues. This study is intended to conduct preliminary clinical transformation and internal irradiation dosimetry research on 177Lu-EB-FAPI--a new 177Lu therapeutic drug modified by Evans Blue (EB) for the first time in the world.

Description

Fibroblast activation protein (FAP) is a serine peptidase on the surface of tumor associated fibroblasts. It belongs to type II transmembrane glycoprotein. It is rich and characteristic expressed in tumor associated fibroblasts. It has special biological characteristics and stable genome. FAP is expressed at a high level in mesenchymal cells during the embryonic period and is inhibited shortly after birth. It is usually not expressed or expressed at a low level in the resting tissues of normal adults, but it is highly expressed in diseases related to tissue repair and matrix reconstruction, such as wound healing, inflammatory response, fibrosis and cancer It plays an important role in metastasis and immunosuppression.Currently, 68Ga labeled FAPI (68Ga-FAPI) has been successfully applied to a variety of tumor PET/CT imaging, including lung cancer, breast cancer, and gastrointestinal tract tumors.By modifying FAPI with Evans blue (EB) to form a new EB-FAPI, endogenous albumin can be used as a reversible carrier to prolong the retention time of drugs in the blood, thus increasing the targeted aggregation and retention of 177Lu-EB-FAPI in tumor cells, and effectively killing a variety of transplanted tumors with positive FAP expression.we'll try to assess the safety and therapeutic response to 177Lu-EB-FAPI in patients with metastatic tumors in human.

Details
Condition 177Lu-EB-FAPI
Treatment 68Ga-FAPI for PET / CT scan and 177Lu-EB-FAPI for therapy
Clinical Study IdentifierNCT05400967
SponsorPeking Union Medical College Hospital
Last Modified on15 June 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

confirmed treated or untreated metastatic tumors patients
Ga-FAPI PET/CT and 18F-FDG PET/CT within two weeks
signed written consent

Exclusion Criteria

pregnancy
breastfeeding
any medical condition that in the opinion of the investigator may significantly interfere with study compliance
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